Impedance-based detection of extracellular DNA in wounds

Autor:	Gerald Gerlach, Angela Rösen-Wolff, Anna Schröter
Rok vydání:	2013
Předmět:	History Pathology medicine.medical_specialty integumentary system Inflammatory response Biology Wound infection Extracellular dna In vitro Infected wound Computer Science Applications Education Healing rate medicine Wound treatment Biomedical engineering
Zdroj:	Journal of Physics: Conference Series. 434:012057
ISSN:	1742-6596 1742-6588
DOI:	10.1088/1742-6596/434/1/012057
Popis:	Wound infection status is a relevant diagnostic parameter to enhance wound treatment towards better healing rate. Impedance evaluation is a powerful tool to measure the inflammatory response like the released DNA of neutrophils. In our research we investigated the dielectric behaviour of neutrophils settled on electrodes in vitro. The cells have been stimulated to react in the same way as in a wound infection. The result is a significant impedance deviation of about 50% with comparable amount of cells like in an infected wound. Microscopic fluorescence verifications acknowledge these findings.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1eaf5e355b135d606b2604f9b2ed3832 https://doi.org/10.1088/1742-6596/434/1/012057 Zobrazit plný text záznamu