Effects of sodium hypochlorite and cigarette smoke on lung function and behavior of Wistar rats
| Autor: | Beatriz Mangueira Saraiva Romanholo, Iolanda F.L.C. Tibério, Renata Pandolpho, Andrezza Luiza Moreira, Francine Maria de Almeida, Milton A. Martins, Soraia Nogueira Felix, Isabela Campaner Macenco, Gilberto Fernando Xavier, F M Arantes, Larissa Baptista Benittes, Isabella Santos de Genaro |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Lung medicine.diagnostic_test business.industry Sodium Hypochlorite chemistry.chemical_element Inflammation respiratory system chemistry.chemical_compound Endocrinology Bronchoalveolar lavage medicine.anatomical_structure chemistry Sodium hypochlorite Internal medicine medicine Cigarette smoke medicine.symptom business Lung function |
| Zdroj: | 6.3 Tobacco, Smoking Control and Health Education. |
| DOI: | 10.1183/13993003.congress-2016.oa3503 |
| Popis: | Background: Cigarette Smoke (CS) and Chorine gas (Cl2),found in cleaning products (sodium hypochlorite-NaClO), are involved in pulmonary diseases. There is a high prevalence of smoking among cleaning workers. These factors may be stressors causing behavior alterations. Objective: To investigate effects of NaClO and CS on lung function and behavior of Wistar rats. Methods:Experimental groups (n=8/each) were:1:Control(C),2:Cigarette Smoke(CS), 3:Hypochlorite(H),4:Cigarette Smoke+Hypochlorite(CSH).Weassessed:behavior usingElevated Plus-Maze (EPM), lung mechanics, bronchoalveolar lavage fluid (BALF), mean linear intercept (LM), airway infiltrate and remodeling. Results:BALF total cells were increased in CS, H and CSH, neutrophils in H and macrophages in CS and CSH compared to C(p Conclusion:Cigarette smoke and hypochlorite increase lung inflammation andairwayedema. Co-exposure to CS and NaClO causes airwayremodeling associated to an attenuation of inflammation.The behavior alterations observed suggest that CS or theco-exposure to CS and NaClO were potential stressors for these animals. |
| Databáze: | OpenAIRE |
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