Punctate pemphigus: an underreported direct immunofluorescence pattern
| Autor: | Christine J. Ko, Jennifer M. McNiff |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Histology integumentary system medicine.diagnostic_test biology Intercellular deposition Pemphigus vulgaris Dermatology Immunofluorescence medicine.disease Immunoglobulin G Pathology and Forensic Medicine Pemphigus medicine.anatomical_structure immune system diseases Desmosome Immunology medicine biology.protein skin and connective tissue diseases Direct fluorescent antibody Pemphigus foliaceus |
| Zdroj: | Journal of Cutaneous Pathology. 41:293-296 |
| ISSN: | 0303-6987 |
| DOI: | 10.1111/cup.12272 |
| Popis: | Intercellular epidermal deposition of immunoglobulin G (IgG) in a continuous net-like or ‘chicken wire’ pattern is a well-described and diagnostic finding in direct immunofluorescence (DIF) studies of pemphigus. In our experience, punctate or dot-like intercellular deposition of IgG can also be seen in cases of pemphigus but has received little attention in the literature. We describe a series of DIF specimens showing intercellular deposition of IgG in continuous and/or punctate patterns, which occurred with equal frequency in pemphigus vulgaris and pemphigus foliaceus. This series highlights the punctate or dot-like pattern of intercellular IgG deposition in DIF studies of pemphigus, reviews potential mechanisms and calls attention to this potentially under-recognized phenomenon. |
| Databáze: | OpenAIRE |
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