Low Blood Content of IL-10-Producing CD4+ T Cells as a Risk Factor for Progression of Coronary Atherosclerosis
| Autor: | E.A. Noeva, S I Provatorov, Aref'eva Ti, V P Masenko, A Yu Filatova, N.V. Radyukhina, E A Pylaeva, A V Potekhina, A M Shchinova, E.A. Klesareva, O I Afanas'eva, N. Yu. Ruleva |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Predictive marker business.industry Inflammation General Medicine Gastroenterology General Biochemistry Genetics and Molecular Biology Coronary arteries 03 medical and health sciences Interleukin 10 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Internal medicine medicine medicine.symptom Risk factor business Prospective cohort study 030217 neurology & neurosurgery Coronary atherosclerosis Lipoprotein |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 166:330-333 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04344-z |
| Popis: | In a 2-year prospective study, prognostic significance of the blood content of IL-10-producing CD4+ T lymphocytes for progression of coronary artery atherosclerosis was assessed. Patients with verified stable angina (n=36) admitted for scheduled coronary angiography and coronary stenting were enrolled. The blood levels of CD4+FoxpP3+ Treg, CD4+IFNγ+ Th1, CD4+IL17+ Th17, CD4+IL10+ cells, sCD25, IL-10, IL-17, C-reactive protein, and lipoprotein (a) were assayed before endovascular interventions. The blood content of CD4+IL10+ T cells below 3.3% was associated with progression of coronary artery atherosclerosis (OR 12.0 (2.3, 61.0), sensitivity 77%, specificity 78%, p=0.003). No differences in other immunological parameters and common atherosclerosis risk factors in the groups were revealed. We hypothesize that the content of CD4+IL10+ T cells can be an important predictive marker for the progression of coronary atherosclerosis. |
| Databáze: | OpenAIRE |
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