Factor XIII Deficiency and Intracranial Bleed: Surgical Management and Prophylaxis with Cryoprecipitate
| Autor: | Rasmi Palassery, Pranoy Hegde, B. P. Karunakara, Sunil V. Furtado |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry medicine.medical_treatment 030204 cardiovascular system & hematology Bleed medicine.disease Factor XIII Surgery 03 medical and health sciences 0302 clinical medicine Hematoma Cryoprecipitate Pediatrics Perinatology and Child Health Magnetic resonance imaging of the brain medicine Factor XIII deficiency Neurology (clinical) Intracranial bleed business 030217 neurology & neurosurgery Craniotomy medicine.drug |
| Zdroj: | Journal of Pediatric Neurology. 20:208-210 |
| ISSN: | 1875-9041 1304-2580 |
| DOI: | 10.1055/s-0041-1731026 |
| Popis: | Factor XIII (FXIII) deficiency is a rare bleeding disorder with affected patients having high propensity for intracranial hemorrhage. A 12-year-old girl presented with severe headache, limb weakness, and rapidly worsening sensorium over 4 days. Magnetic resonance imaging of the brain and computed tomography (CT) of the head showed intraparenchymal bleed. Patient had normal coagulation profile and abnormal FXIII level. The perioperative management included cryoprecipitate transfusion to bring the FXIII value to 74%. She underwent craniotomy and evacuation of the hematoma. Postoperatively, she received prophylaxis against rebleed with cryoprecipitate. In the absence of FXIII concentrate, correction of FXIII deficiency is possible with cryoprecipitate in emergent situations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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