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Objective: To compare the effects of metformin and chromium pico- linate on females with polycystic ovarian syndrome. Background: Polycystic ovarian syndrome is the most common en- docrinopathy of reproductive-aged women. It presented with exces- sive hair growth(hyperandrogenism), menstrual irregularities (an- ovulation), and polycystic ovaries.They are commonly accompanied by obesity, insulin resistance, and infertility. Methods: Sixty female patients with polycystic ovarian syndrome were enrolled for our study at Suez Canal University Hospitals, from January 2016 to December 2016. They were randomly assigned into 2 groups. FSH, LH, testosterone, TSH, prolactin, fasting blood sug- ar, fasting insulin, QUICKI, HOMA-IR were measured for all pa- tients. The first group received metformin 500 mg twice daily while the other group received chromium picolinate 200 μg once daily for 3 months. Results: Fifty-four patients completed the study, we compared the effect of metformin and chromium in patients with PCOs, it showed significant difference regarding free testosterone, serum prolactin (p=0.01), FSH level, FBS, Fasting insulin and QUIKI between the two groups (p=0.001). In Group I, there was significant difference regarding the values of BMI, free testosterone, TSH, fasting blood sugar, fasting insulin, HOMA-IR, QUICKI, ovarian volume(p |
