| Popis: |
The objective of present study aims to formulate enclosed floating alginate beads of Prochlorperazine Maleate (PCZM) for the treatment of nausea and vomiting. The Prochlorperazine Maleate which is having lower bioavailability up to 12.5% and also, it’s a lower biological half-life so which required multiple dosing frequencies 3-4 times a day. Bioavailability refers that to extend and rate at which the active moiety enters into the systemic circulation to the site of action. Biological half-life is the time that a body requires to eliminate one-half the quantity of an administered substance. So, by using Floating Alginate Beads of Prochlorperazine maleate which is help to Produced sustained released action up to 12 hours. Hence, it helpful for improvement of bioavailability and biological half-life, and reduced frequency of dosing. The Prochlorperazine Maleate (PCZM) beads were formulated by the Ionotropic gelation method by sodium alginate solution containing Low methylated pectin in various ratios. The Preformulation study was performed like Physical characters, Drug Excipients compatibility study by Calibration curve, FTIR and DSC study. The floating alginate beads were evaluated by different parameters like Percentage yield, Drug Content (DC) & Entrapment Efficiency (EE), In-vitro Drug Release study, particle size analysis, Z-Potential, SEM, PXRD, Stability study. The result of the FT-IR and DSC study indicated the stability and compatibility of the drug & polymers. The standard calibration curve in 0.1 N HCl (pH 1.2) showed a regression of 0.999. The percentage yield was found to be 86.29% to 95.90%. The drug content was found to be 3.7- 4.7 mg. The percentage buoyancy was found to be 89.40% to 97.50%. The in-vitro drug release study of the formulated batch was ranged from 77.29% to 91.44% at the end of 12 h. The best formulation was selected as batch B-2 which gives the best result based on Percentage Yield, DC, EE, buoyancy study, and In-vitro Drug Released st |
