Detection of autoantibodies against GABAARα1 in patients with schizophrenia
| Autor: | Hiroki Shiwaku, Maiko Kato, Yuri Nakano, Hidehiko Takahashi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
biology
business.industry Cell Autoantibody Antibody titer Disease medicine.disease 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine medicine.anatomical_structure Schizophrenia Immunology biology.protein Medicine Antibody Receptor business 030217 neurology & neurosurgery Biological Psychiatry Encephalitis |
| Zdroj: | Schizophrenia Research. 216:543-546 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2019.10.007 |
| Popis: | Recent studies have identified autoantibodies against synaptic molecules in patients with encephalitis. Autoantibodies against the N-Methyl-d-Aspartate receptor have been reported in patients with schizophrenia; however, autoantibodies against other molecules are yet to be identified. This study used a cell-based assay to examine serum samples from individuals with schizophrenia and healthy controls. The results showed that 5 (8.6%) of 57 patients with schizophrenia harbor autoantibodies against the α1 subunit of the γ-aminobutyric acid A receptor (GABAARα1), which are currently not know to be linked to the pathology of this disease. Some patients showed markedly high antibody titers (i.e., 1:10,000-100,000). None of the heathy control subjects were positive for GABAARα1 antibodies. Therefore, these autoantibodies may form the basis of GABA-mediated pathology in a subgroup of patients with schizophrenia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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