Azadirachtin, a neem-derived biopesticide, impairs behavioral and hematological parameters in carp (Cyprinus carpio)
| Autor: | Camila Murussi, Charlene Menezes, Maria do Carmo Araújo, Mauro Eugênio Medina Nunes, Vania Lucia Loro, Denis B. Rosemberg, Vanessa A. Quadros |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis Organic production 010501 environmental sciences Management Monitoring Policy and Law Biology Hematocrit Pharmacology Toxicology 01 natural sciences Cyprinus 03 medical and health sciences chemistry.chemical_compound medicine Carp 0105 earth and related environmental sciences medicine.diagnostic_test General Medicine biology.organism_classification Biopesticide 030104 developmental biology Azadirachtin chemistry Acute exposure Hemoglobin |
| Zdroj: | Environmental Toxicology. 31:1381-1388 |
| ISSN: | 1520-4081 |
| Popis: | Azadirachtin (Aza) is a promisor biopesticide used in organic production and aquaculture. Although this compound is apparently safe, there is evidence that it may have deleterious effects on fish. Behavioral and hematological tests are grouped into a set of parameters that may predict potential toxicity of chemical compounds. Here, we investigate the effects of Aza, in the commercial formulation Neenmax™ , on carp (Cyprinus carpio) by defining LC50 (96 h), and testing behavioral and hematological parameters. In our study, LC50 was estimated at 80 μL/L. We exposed carp to Aza at 20, 40, and 60 μL/L, values based on 25, 50, and 75% of LC50 , respectively. At 60 μL/L, Aza promoted significant changes in several parameters, increasing the distance traveled and absolute turn angle. In addition, the same concentration decreased the time spent immobile and the number of immobile episodes. Hematological parameters, such as hematocrit, hemoglobin, hematimetrics index, and red cell distribution, were decreased at 60 μL/L Aza exposure. In conclusion, our study demonstrates that 60 μL/L Aza altered locomotor activity, motor pattern, and hematological parameters, suggesting potential toxicity to carp after acute exposure. In addition, this is the first report that evaluates the actions of a chemical contaminant using automated behavioral tracking of carp, which may be a useful tool for assessing the potential toxicity of biopesticides in conjunction with hematological tests. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1381-1388, 2016. |
| Databáze: | OpenAIRE |
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