Synthesis, characterization and biological evaluation of some novel 2-substituted mercaptobenzimidazole derivatives

Autor:	K. Durga Prasad, Malladi Srinivas Reddy, P. Arvinda Reddy, Ravinder Nath Anisetti, Santanu Sannigrahi
Rok vydání:	2011
Předmět:	Pharmacology Antifungal Chemistry medicine.drug_class Drug Discovery Pharmacology toxicology medicine Organic chemistry Spectral data Antimicrobial Biological evaluation
Zdroj:	Pharmaceutical Chemistry Journal. 44:642-645
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-011-0537-7
Popis:	Synthesis and biological assessment of six novel 2-substituted mercaptobenzimidazole derivatives is performed. The title compounds are characterized by their analytical and spectral data. All the synthesized compounds are screened for their anti-ulcer and anti-microbial activity. 2-(1H-benzimidazole-2-sulfinyl) –N-(4-benzyloxy-phenyl)-acetamide, N-(4-benzyloxy-phenyl)-4-(1H-benzimidazole-2-sulfinyl)-butyramide, N-(4-benzyloxy phenyl)-4-(5-methoxy 1H-benzimidazole-2-sulfinyl)-butyramide showed significant antiulcer activity. All the compounds moderate antibacterial and antifungal activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1e8b8fd5dc2a43ce28785dc38c4ba3b4 https://doi.org/10.1007/s11094-011-0537-7 Zobrazit plný text záznamu Plný text ve formátu PDF