ChemInform Abstract: Studies on Antifungal Agents. In vitro Activity of Novel cis-5-Alkoxy-(or Acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine Derivatives

Autor:	S. D. Allen, J. T. Mitchell, V. St. Georgiev, David M. Maryniak, George B. Mullen, C. R. Kinsolving
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Antifungal medicine.drug_class Candida stellatoidea General Medicine Medicinal chemistry In vitro chemistry Alkoxy group medicine Potency Ketoconazole Alkyl medicine.drug
Zdroj:	ChemInform. 21
ISSN:	0931-7597
DOI:	10.1002/chin.199023316
Popis:	The synthesis and in vitro antifungal activity of a novel series of cis-5-alkoxy(or acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)- 2-methylisoxazolidine derivatives (6a-n) are described. The 5-[(4-chlorobenzyloxy)methyl] analogue 6h and the two 5-acyloxymethyl derivatives 6k,l demonstrated the best overall potency. Against Candida stellatoidea, the minimum inhibitory concentrations (MIC's) for 6h,k,l ranged between 0.7 and 2.0 micrograms/ml. The corresponding value for the standard drug ketoconazole was 7-20 micrograms/ml.
Databáze:	OpenAIRE
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