The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial
| Autor: | P. Busaracome, B. Sripanidkulchai, Pongdech Sarakarn, C. Choonhakarn |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Randomization biology business.industry Dermatology biology.organism_classification Placebo Chronic inflammatory disease medicine.disease Gastroenterology Aloe vera law.invention Surgery Clinical trial stomatognathic diseases stomatognathic system Randomized controlled trial law Oral administration Internal medicine medicine Oral lichen planus business |
| Zdroj: | British Journal of Dermatology. 158:573-577 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.2007.08370.x |
| Popis: | Summary Background Oral lichen planus (OLP) is a chronic inflammatory disease that can be painful especially in the atrophic and erosive forms. Several therapies have been tried, with varying results. There is one case report in which aloe vera (AV) was used successfully in the treatment of lichen planus. Objectives To compare the efficacy of AV and placebo in the topical management of OLP. Methods A randomized, double-blind, placebo-controlled trial was designed. Fifty-four patients were randomized into two groups to receive AV gel or placebo for 8 weeks. Results Fifty-four consecutive patients (34 women and 20 men) participated in the study. We found erosive and ulcerative lesions in 83% and 17%, respectively. The most common site of OLP was the lower lip. Twenty-two of 27 patients treated with AV (81%) had a good response after 8 weeks of treatment, while one of 27 placebo-treated patients (4%) had a similar response (P |
| Databáze: | OpenAIRE |
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