Statut thyroïdien et fréquences des dysthyroïdies chez les adultes inclus dans l’étude SU.VI.MAX en 1994-1995
| Autor: | Serge Hercberg, C. Cousty, P. Valeix, C. Dos Santos, Sandrine Bertrais, Katia Castetbon |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Gynecology
endocrine system medicine.medical_specialty education.field_of_study endocrine system diseases Cross-sectional study business.industry Endocrinology Diabetes and Metabolism Population Thyroid General Medicine Endocrinology medicine.anatomical_structure Thyroid-stimulating hormone Cohort Epidemiology medicine Geometric mean Thyroid function education business |
| Zdroj: | Annales d'Endocrinologie. 65:477-486 |
| ISSN: | 0003-4266 |
| DOI: | 10.1016/s0003-4266(04)95956-2 |
| Popis: | Abnormal thyroid function has important public health consequences. However, the various degrees of thyroid dysfunction remain unsettled. The SU.VI.MAX cohort provided a unique opportunity to conduct a cross-sectional study of abnormal thyroid function in a large representative population of 11256 men and women representing the geographic distribution of the French continental adult population. Thyroid status was measured, in fasting blood samples, at baseline in 1994-1995. Serum thyrotropin (TSH) levels (abnormal or =4.0 mU/l) and free thyroxine (fT4) were both performed in duplicate on the same sample. Subjects with previous or present thyroid diseases or who were taking thyroid hormones or antithyroid drugs (n=920) were excluded (8.1%). Thus, the final study group consisted of 10346 subjects, 4121 men aged 45-60 years (mean +/-SD) (51.8+/-4.7 yrs), 2641 women aged 35-44 years (40.6+/-2.8 yrs), and 3584 women aged 45-60 years (51.4+/-4.4 yrs). Median (2.5th and 97.5th percentiles) for TSH (mU/l) were 1.52 (0.20-4.54) for men, 1.78 (0.22-5.54) for women aged 35-44 years, and 1.96 (0.22-6.80) for women aged 45-60 years. The TSH distribution of women was shifted to the right compared with men. Arithmetic mean fT4 (+/-SD) was 10.7+/-1.7 ng/l (13.8 +/-2.2 pmol/l) for men and 10.9+/-1.8 ng/l (14.0+/-2.3 pmol/l) for women. The prevalence of abnormal TSH values in men, and in women (35-44 yrs and 45-60 yrs) were TSH or =10.0 mU/l 0.2%, 0.4% and 0.7%, respectively. Geometric mean serum TSH and arithmetic mean serum fT4 concentrations showed significant overall inter-regional differences for men and women (p or =45 yrs) (p=0.04) exclusively. Over the age of 45 years, the women: men ratio for unrecognized elevated TSH levels (> or =4.0 mU/l) was 2.82, whereas it was 0.64 for low TSH levels ( |
| Databáze: | OpenAIRE |
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