Effect of Aqueous Extract of F. capensis Leaves and Its Combination with C. aconitifolius Leaves on Essential Biochemical Parameters of Phenylhydrazine-Induced Anemic Rats

Autor:	Obiajulu Christian Ezeigwe, Favour Amarachi Nzekwe, Kingsley Kelechi Asogwa, Chidinma Felicia Ezennaya, Ogechukwu Frances Nworji, Ebele Lauretta Iloanya
Rok vydání:	2020
Předmět:	Pharmacology chemistry.chemical_classification medicine.medical_specialty biology Bilirubin Cholesterol Glutathione peroxidase Aspartate transaminase Malondialdehyde biology.organism_classification chemistry.chemical_compound Endocrinology chemistry Alanine transaminase Internal medicine medicine biology.protein Molecular Medicine Pharmacology (medical) Liver function Cnidoscolus aconitifolius
Zdroj:	Journal of Experimental Pharmacology. 12:191-201
ISSN:	1179-1454
Popis:	Background Ficus capensis Moraceae and Cnidoscolus aconitifolius Euphorbiaceae leaves have been used separately in traditional medical practice to treat different ailments, of which anemia is one. This study aims to evaluate the effect of F. capensis and C. aconitifolius on hepatic, renal parameters and oxidative stress of phenylhydrazine-induced anemic rats. Methods Thirty-five rats were randomized into seven groups (A-G) of five rats each. Groups A and B served as the normal control and anemic control, respectively, while Groups C, D, E, F, and G were treated with a standard drug (vitamin B12), 200mg/kg bw. aqueous extract of F. capensis, 400mg/kg b.w. aqueous extract of F. capensis, 200mg/kg bw. of a combination of aqueous extract of F. capensis and C. aconitifolius and 400mg/kg bw. of a combination of aqueous extract of F. capensis and C. aconitifolius, respectively. The biochemical analysis (liver and kidney function analysis, oxidative stress) was carried out using standard diagnostic techniques. Results The results showed that there was significant decrease (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1e7e332048a472933101bb43a740f2bf https://doi.org/10.2147/jep.s254003 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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