| Autor: |
Norio Matsuki, Sakiko Ujita, Yoshitaka Oku, Yuji Ikegaya, Yasumasa Okada, Kenji F. Tanaka, Takuya Sasaki, Megumi Seki, Naoya Takahashi |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
The Journal of Physiology. 590:4933-4944 |
| ISSN: |
0022-3751 |
| DOI: |
10.1113/jphysiol.2012.231464 |
| Popis: |
otC), is the kernel for respiratory rhythm generation. Despite previous extensive studies focusing on neurons,themechanismofhowrespiratoryrhythmisgeneratedhasnotbeenfullyunderstood. • Here we show that non-neuronal glial cells (a subset of putative astrocytes) in the preB¨ are periodically activated preceding inspiratory neuronal activity, periodic activity of putative astrocytes persists during blockade of neuronal activity, and stimulation of astrocytes in the preB¨ otC induces inspiratory neuronal firings. • These findings together with the previous report that blockade of astrocytic metabolism abolishes inspiratory neural output suggest that astrocytes are functionally involved in respiratory rhythm generation. • These results will help us better understand how respiratory rhythm is generated and how respiratory output is disturbed in various pathological conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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