Studies on carboxylation of alkoxy-substituted benzyl alcohols via direct lithiation and bromine-lithium exchange: Synthesis of phthalides and phthalideisoquinoline alkaloids

Autor:	Kazuhiko Orito, Mamoru Miyazawa, Hiroshi Suginome
Rok vydání:	1995
Předmět:	Bromine chemistry Carboxylation Organic Chemistry Drug Discovery Alkoxy group chemistry.chemical_element Organic chemistry Lithium Biochemistry
Zdroj:	Tetrahedron. 51:2489-2496
ISSN:	0040-4020
DOI:	10.1016/0040-4020(95)00003-q
Popis:	Conversion of alkoxy-substituted benzyl alcohols to the corresponding phthalides by carboxylation via ortho lithiation and bromine-lithium exchange was studied. The method was applied to the key step in the synthesis of phthalideisoquinoline alkaloids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1e6d6d14afd38159f376794681c83a8a https://doi.org/10.1016/0040-4020(95)00003-q Zobrazit plný text záznamu Full Text from ScienceDirect