Evaluation of silica hydride materials for the LC–MS analysis of cathinones and benzylpiperazines
| Autor: | Kavita Alejo, Arlette Lopez, Diana Orozco, Maria T. Matyska, Linda Doan, Joseph J. Pesek, Seiichiro Watanabe, Margaryta Makhanov |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution Chromatography Hydride 010401 analytical chemistry Diol Salt (chemistry) 01 natural sciences 0104 chemical sciences Pathology and Forensic Medicine Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Liquid chromatography–mass spectrometry Materials Chemistry Amine gas treating 030216 legal & forensic medicine Physical and Theoretical Chemistry Silica hydride Law Spectroscopy Bath salts |
| Zdroj: | Forensic Chemistry. 8:90-94 |
| ISSN: | 2468-1709 |
| Popis: | A new LCMS approach is tested for the analysis of controlled substances using bath salts (cathinones) as a model system. Since the structure of cathinones have a polar functionality (the amine group) as well as an aromatic component, separation on the LC column could be achieved in the reversed-phase(RP) or aqueous normal phase (ANP) modes. Since silica hydride columns can function in both modes they have considerable potential for the analysis of substances that have both polar and nonpolar functionalities. Four different silica hydride-based columns (C18, phenyl, cholesterol and diol) are tested in either the RP or ANP and RP modes using representative compounds to determine their applicability to bath salt analysis. A protocol for the analysis of a related illicit drug, benzylpiperazine, is developed on another silica hydride column (Diamond Hydride) in the ANP mode. Further testing is done on physiological samples, saliva (with 78–98% recovery) and hair, in order to determine that the approach outlined in this study could be utilized for these and other controlled substances in biological matrices. |
| Databáze: | OpenAIRE |
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