Lipase catalyzed transesterification of 2-substituted 3-hydroxy esters

Autor:	Kouhei Goto, Tomiki Takahashi, Harumi Kaga, Kunio Hirosawa
Rok vydání:	1998
Předmět:	Pharmacology biology Chemistry Organic Chemistry Transesterification Catalysis Analytical Chemistry Kinetic resolution Stereocenter chemistry.chemical_compound Drug Discovery biology.protein Vinyl acetate Organic chemistry Lipase Chirality (chemistry) Spectroscopy Methyl group
Zdroj:	Chirality. 10:693-698
ISSN:	1520-636X 0899-0042
DOI:	10.1002/(sici)1520-636x(1998)10:7<693::aid-chir15>3.0.co;2-v
Popis:	Kinetic resolution of 2-substituted 3-hydroxy esters was examined by lipase PS catalyzed transesterification using vinyl acetate as an acyl donor. Resolution of (±)-syn- and -anti-1a, -1e possessing a small methyl group at the C-3 position was accomplished enantioselectively. The outcome of the resolution seems to be related to the differences in size of the substituents at the stereocenter bearing a secondary hydroxy group. Chirality 10:693–698, 1998. © 1998 Wiley-Liss, Inc.
Databáze:	OpenAIRE
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