Synthesis and cell transfection properties of cationic uracil-morpholino tetramer

Autor:	Sankha Pattanayak, Surajit Sinha, Sibasish Paul
Rok vydání:	2014
Předmět:	chemistry.chemical_classification animal structures Morpholino Chemistry Stereochemistry Biomolecule Organic Chemistry Cationic polymerization Uracil Transfection Biochemistry chemistry.chemical_compound Tetramer embryonic structures Drug Discovery Biophysics Azide BODIPY
Zdroj:	Tetrahedron Letters. 55:1072-1076
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.12.087
Popis:	Synthesis and cell transfection properties of guanidinium-functionalized uracil morpholino tetramer have been reported for the first time. Due to the basic nature of guanidinium groups they remain protonated under physiological conditions. Such cationic tetramer exhibits efficient cellular uptake properties as visualized by microscopy imaging using fluorescent dye BODIPY. 7′-End of this morpholino tetramer was functionalized with an azide group for conjugation with various types of biomolecules or drugs for cellular delivery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1e667752104dcd85ecee1617076924c2 https://doi.org/10.1016/j.tetlet.2013.12.087 Zobrazit plný text záznamu Full Text from ScienceDirect