Leishmania (Viannia) guyanensis Induces Low Immunologic Responsiveness in Leishmaniasis Patients from an Endemic Area of the Brazilian Amazon Highland
| Autor: | Leonor L. Leon, Marise Mattos, Ilner de Souza e Souza, Antonia Maria Ramos Franco, Nubia E. Matta, Alda Maria Da-Cruz, Manoel P. Oliveira-Neto, R. S. Nogueira, Sergio G. Coutinho |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 80:339-344 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.2009.80.339 |
| Popis: | Cutaneous leishmaniasis caused by Leishmania ( Viannia ) guyanensis (CL-Lguy) is endemic in the Brazilian Amazon, differing from L. braziliensis infection in clinical, diagnostic, and therapeutic aspects. T-cell reactivity to leishmanial antigens possibly involved in the pathogenesis of CL-Lguy was studied herein. Variable lymphoprolif- erative responses (LPRs) to Leishmania antigens were found among the 23 studied patients, and 50% of them showed low or no response to these antigens. Active disease was associated with an enrichment of leishmanial-reactive T lympho- cytes, mainly TCD4 + . High and low interferon (IFN)-g producers were observed. TNF-a, interleukin (IL)-10, and IL-5 were consistently detected. CL-Lguy displayed low antibody response in comparison to L. braziliensis patients. CL caused by L. braziliensis presented positive LPRs and higher IFN-g production but undetectable IL-5. L. guyanensis seems to induce a down-regulation of the immune system compared with L. braziliensis. This finding could explain some aspects of clinical presentation of CL-Lguy, such as high tissue parasite burden and frequent resistance to therapy. |
| Databáze: | OpenAIRE |
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