Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus

Autor:	R Quartey-Papafio, T Lund, P Chandler, J Picard, P Ozegbe, S Day, P R Hutchings, L O'Reilly, D Kioussis, E Simpson
Rok vydání:	1995
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 154:5567-5575
ISSN:	1550-6606 0022-1767
Popis:	MHC class II genes have been shown to influence the development of the autoimmune disease insulin-dependent diabetes mellitus (IDDM) in the nonobese diabetic (NOD) mouse. In human IDDM it has been suggested that the presence of an aspartate at position 57 of the DQ beta-chain might be important in determining resistance to development of IDDM. The involvement of MHC class II genes in IDDM was investigated through the introduction of MHC encoding transgenes. We show that introduction of a mutated I-Ag7 Ab gene which encodes an aspartate at position 57 reduces the incidence of IDDM but does not prevent insulitis, sialadenitis, or the development of insulin and nuclear autoantibodies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1e3d47c65d5e755b805b16c5f41c7a2f https://doi.org/10.4049/jimmunol.154.10.5567 Zobrazit plný text záznamu