Five hours total sleep deprivation does not affect CA1 dendritic length or spine density

Autor:	Katrin Wellfelt, Gabulya S, Tobias Karlsson, Alvin T. S. Brodin
Rok vydání:	2021
Předmět:	Genetically modified mouse medicine.medical_specialty Dendritic spine Long-term memory business.industry Hippocampal formation Affect (psychology) Sleep in non-human animals Spine (zoology) Sleep deprivation Endocrinology Internal medicine medicine medicine.symptom business
DOI:	10.1101/2021.02.04.429550
Popis:	Sleep is essential for long term memory function. However the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of acute sleep deprivation on the dendritic architecture of hippocampal CA1 pyramidal neurons. We found that five hours of sleep deprivation had no effect on either dendritic length or dendritic spine density. Our work suggests that no major neuroanatomical changes result from one episode of sleep deprivation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1e219e785f1cf626bbcad3106bd5018f https://doi.org/10.1101/2021.02.04.429550 Zobrazit plný text záznamu