| Autor: |
Morey, R.A., Garrett, M.E., Roberts, A.L., Ratanatharathorn, A., Kessler, R.C., Gelernter, J., Dalvie, S., Hauser, M.A., Almli, L.M., Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup, Smoller, J.W., Baker, D.G., Ashley-Koch, A.E., Chen, C.-Y., Nugent, N.R., Rice, J.P., Farrer, L.A., Miller, M.W., Aiello, A.E., Nievergelt, C.M., Duncan, L.E., Bierut, L.J., Bradley, B., Wildman, D.E., Daly, M.J., Koen, N., Polimanti, R., Amstadter, A.B., Ressler, K.J., Galea, S., King, A., Bisson, J., Guffanti, G., Sumner, J.A., Kimbrel, N.A., Johnson, E.O., Maihofer, A.X., Ripke, S., Kranzler, H.R., Yehuda, R., Koenen, K.C., Ursano, R.J., Beckham, J.C., Uddin, M., Gelernter, J.E., Liberzon, I., Zhao, H., Saccone, N.L., Stein, M.B., Martin, A.R., Stein, D.J., Logue, M.W. |
| Rok vydání: |
2017 |
| DOI: |
10.17615/qc1a-7z17 |
| Popis: |
Background: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. Methods: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3577 European American women (966 PTSD cases and 2611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships. Results: We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, independent of body mass index (BMI). The top association was related to BMI-adjusted waist circumference (WCadj; R = -0.079, P < 0.001, Q = 0.011). We estimated a relative decrease of 64.6% (95% confidence interval = 27.5-82.7) in the risk of PTSD per 1-SD increase in WCadj. MR-Egger regression intercept analysis showed no evidence of pleiotropic effects in this association (Ppleiotropy = 0.979). We also observed associations of genetically determined WCadj with age at first sexual intercourse and number of sexual partners (P = 0.013 and P < 0.001, respectively). Conclusions: There is a putative causal relationship between genetically determined female body shape and PTSD, which could be mediated by evolutionary mechanisms involved in human sexual behaviors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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