ChemInform Abstract: Synthesis and Biological Evaluation of 6-(9-Hydroxy-5-methyl (and 5,6- Dimethyl)-6H-pyrido(4,3-b)carbazol-1-yl)picolinic Amides as New Olivacine Derivatives

Autor:	Claude Guillonneau, Laurence Kraus-Berthier, R. Jasztold‐Howorko, Emile Bisagni, C. Landras, Alain Pierré, Ghanem Atassi, Yves Rolland, Stéphane Léonce, Nicolas Guilbaud
Rok vydání:	2010
Předmět:	chemistry.chemical_compound In vivo Stereochemistry Chemistry Lewis lung carcinoma General Medicine Olivacine Ethylamine Cytotoxicity Lead compound B16 melanoma Biological evaluation
Zdroj:	ChemInform. 28
ISSN:	0931-7597
Popis:	Starting from 2-(6-methoxy-1-methylcarbazol-2-yl)ethylamine and diethyl-2, 6-pyridine dicarboxylate, the title compounds were obtained through five or six steps. The new compounds retained significant cytotoxicity towards various tumor cell lines, but in vivo studies on murine P388 leukemia, B16 melanoma and Lewis lung carcinoma showed a lowered antitumor activity with respect to that of the related ovivacine lead compound 1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1e16117b4d1fad56ed2267244ac9ed5b https://doi.org/10.1002/chin.199721158 Zobrazit plný text záznamu Plný text