Improved synthesis of bioactive stilbene derivatives applying design of experiments to the Heck–Matsuda reaction

Autor:	Carla Cristina Perez, Jesus M. Pena, Carlos Roque D. Correia
Rok vydání:	2014
Předmět:	Reaction conditions Chemistry Design of experiments Materials Chemistry Organic chemistry General Chemistry Heck–Matsuda reaction Combinatorial chemistry Catalysis
Zdroj:	New J. Chem.. 38:3933-3938
ISSN:	1369-9261 1144-0546
DOI:	10.1039/c4nj00601a
Popis:	Design of experiments was employed to optimize the reaction conditions used to synthesize stilbene derivatives. New Heck conditions were tested using several styrenes and aryldiazonium tetrafluoroborates, generating the desired stilbenes in good yields in all cases under very practical, economical and effective conditions. This methodology was used for the synthesis of bioactive stilbenes such as resveratrol, DMU-212, and their analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1e153d7f01c651cdb1835ac18fa36887 https://doi.org/10.1039/c4nj00601a Zobrazit plný text záznamu