ChemInform Abstract: Synthesis and Reactivity of Michael Adducts of Cyclic β-Ketoesters Enolates with Electrophilic Acetylenes

Autor:	Michel Franck-Neumann, Michel Miesch, Gaëtan L.A. Mislin
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Addition reaction Aldol reaction Chemistry Intramolecular force Electrophile Robinson annulation Organic chemistry Reactivity (chemistry) General Medicine Toluene Catalysis
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199849101
Popis:	The enolates of cyclic β-ketoesters react with electrophilic acetylenes to give the corresponding Michael adducts in good yields when the reaction is performed in acetone in the presence of catalytic amounts of K2CO3. The Michael adducts resulting from ethynylmethylketone, when refluxed in toluene in the presence of catalytic amounts of pTsOH, undergo an intramolecular aldol reaction leading mainly to bicyclo [n. 3. 1]alkadienones besides Robinson annulation products.
Databáze:	OpenAIRE
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