In Vivo and In Vitro Studies of Plasma Post-Heparin Lipolytic Activity in Subjects with Hyperchylomicronemia (Fat-Induced Lipemia)
| Autor: | Reagan H. Bradford, Helen B. Bass, Robert H. Furman |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
medicine.medical_specialty
Hypertriglyceridemia Phospholipid Post-heparin lipolytic activity medicine.disease In vitro chemistry.chemical_compound Chain length Endocrinology chemistry In vivo Internal medicine medicine lipids (amino acids peptides and proteins) Lipoprotein lipase activity Chylomicron |
| Zdroj: | Drugs Affecting Lipid Metabolism ISBN: 9781461568681 |
| DOI: | 10.1007/978-1-4615-6866-7_14 |
| Popis: | Havel and Gordon (1), in 1960, described three hyperglyceridemic siblings (“P” family) in whom plasma post-heparin lipoprotein lipase activity was diminished. This disorder is relatively rare (2) and is characterized by markedly increased serum triglyceride levels with little if any increase of serum cholesterol and phospholipid values (3,4). The hypertriglyceridemia is due to the retention in the blood of cholesterol-poor chylomicrons, hence the designation “hyperchylomicronemia” (3) or “fat-induced” lipemia (4). Serum triglyceride levels in these subjects may be reduced by withholding dietary fat (1) or by providing triglycerides containing medium chain length (C8 and C10) fatty acids, as the sole source of dietary fat (5). |
| Databáze: | OpenAIRE |
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