THE EFFECT OF LARGE DOSES OF TESTOSTERONE PROPIONATE (ORETON) ON THE FEMALE GENITALTRACT OF THE VERY YOUNG RAT. PRODUCTION OF OVARIAN CYSTS

Autor:	Karl E. Paschkis, Samuel S. Fels, Jacob Gershon-Cohen, Harry Shay
Rok vydání:	1939
Předmět:	Testosterone propionate Estrous cycle Pituitary gland medicine.medical_specialty Uterus Clitoris Ovary Biology chemistry.chemical_compound Endocrinology medicine.anatomical_structure Sex hormone-binding globulin chemistry Internal medicine medicine biology.protein Testosterone
Zdroj:	Endocrinology. 25:933-943
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-25-6-933
Popis:	EXTENSIVE studies of the effects of the male sex hormones on female experimental animals have been made, which report changes in ovaries, uterus, female prostate, clitoris, adrenals, pituitary and estrous cycle. The results are not usually comparable because different androgenic compounds were used. However, the effect of really large doses of male sex hormone did not seem to us to be definitely settled. What dosage shall be considered large is obviously an open question but it seemed to be of some interest to study prolonged treatments with doses generally higher than those reported. The experiments reported in this paper were performed on Wistar strain rats under constant conditions of food, light and temperature. Subcutaneous injections of testosterone propionate1 were started on the first or second day of life. Litter2mate controls were used throughout the experiment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1df6e95a02b25c9130632c7aae424471 https://doi.org/10.1210/endo-25-6-933 Zobrazit plný text záznamu