Growth Hormone Secretagogues Stimulate the Hypothalamic-Pituitary-Adrenal Axis and Are Diabetogenic in the Zucker Diabetic Fatty Rat1
| Autor: | Keith M. Fairhall, I. C. A. F. Robinson, G. B. Thomas, Y. H. Ma, Wesley Won, Ross G. Clark, Deborah L. Mortensen, E.E. Tomlinson |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Growth factor medicine.medical_treatment Insulin Biology medicine.disease Pentapeptide repeat Somatropin chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Corticosterone Growth hormone secretagogue Internal medicine Diabetes mellitus medicine Hypothalamic–pituitary–adrenal axis |
| Zdroj: | Endocrinology. 138:4316-4323 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.138.10.5424 |
| Popis: | Besides stimulating GH release, some GH secretagogues also release ACTH and adrenal steroids. Several novel classes of potent GH secretagogues have recently been described, and we have now tested their ability to release corticosterone in conscious normal rats. All analogs that released GH also stimulated corticosterone release to some degree, though the relative effects on GH and corticosterone varied somewhat. The corticosterone responses for some analogs were in the range of those obtained with CRF (2 μg, iv), whereas closely related analogs inactive for GH release failed to release corticosterone. Activation of the hypothalamic-pituitary-adrenal axis with GH release by GHRPs could be a highly diabetogenic combination in susceptible individuals. Therefore, a potent GHRP pentapeptide analog (G7039, 100μ g/day, sc, bid) was given to young obese male Zucker diabetic fatty rats (ZDF, n = 8/group) for 24 days. Other groups received hGH (500 μg/day, sc, bid), recombinant human insulin-like growth factor (rhI... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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