Visualization of Synapses and Synaptic Plasticity in the Drosophila Brain
| Autor: | Thomas Riemensperger, Florian Bilz, André Fiala |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0303 health sciences
Synaptic scaling Synaptogenesis Nonsynaptic plasticity Neurotransmission Biology 03 medical and health sciences 0302 clinical medicine Synaptic fatigue nervous system Synaptic plasticity Metaplasticity Developmental plasticity Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Decoding Neural Circuit Structure and Function ISBN: 9783319573625 |
| Popis: | Drosophila represents a favorable model organism to analyze neuronal circuits underlying behavior. This is mainly due to the versatile genetic tools by which transgene expression can be targeted to virtually any neuronal population in the brain. Fluorescent sensor proteins enable one to monitor the physiological parameters correlating with the function of neurons, and a number of actuator proteins exist that can be used to selectively manipulate distinct neurons. However, the mode of operation of neuronal circuits for determining behavior is not only based on a static connectivity between neurons, but also on the physiological properties of synaptic transmission and their plasticity. Techniques to detect many synapses at high resolution across many neurons in vivo and to access their physiology and plasticity are required. Here, we summarize recent genetic approaches to visualize synapses and to analyze synaptic plasticity in the Drosophila brain. |
| Databáze: | OpenAIRE |
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