Determination of Therapeutic Substance Sibutramine Using Physicochemical Methods in the Composition of Multicomponent Biologically Active Food Supplements
| Autor: | A. M. Sukhanova, N. I. Ponomareva, K. I. Éller, G. M. Rodionova, I. B. Perova, V. I. Gegechkori, D. I. Zhilyaev |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Drug food.ingredient 010405 organic chemistry Chemistry media_common.quotation_subject Food additive 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry food Drug Discovery medicine Russian federation Composition (visual arts) Food science Sibutramine medicine.drug media_common |
| Zdroj: | Pharmaceutical Chemistry Journal. 54:1173-1177 |
| ISSN: | 1573-9031 0091-150X |
| DOI: | 10.1007/s11094-021-02338-8 |
| Popis: | The problem of the illegal addition of the drug sibutramine to biologically active food supplements (BAFS) and their dissemination into the territories of the Russian Federation are discussed. The aim of the present work was to develop methods for preliminary and confirmatory detection of sibutramine in BAFS. TLC was used for screening and instrumented methods such as HPLC-MS and GC-MS were used for confirmation, with the objective of controlling the import and circulation of the illegal food additive sibutramine to BAFS. Methanol and components of the BAFS had no effect on sibutramine detection, confirming the specificity of the method. Application of these methods detected sibutramine in four of eight BAFS samples. |
| Databáze: | OpenAIRE |
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