An unsuspected case of cerebral toxoplasmosis: case report and literature review
| Autor: | C. Soon Lee, Sanaz Sasani, Christopher Henderson, Joo-Shik Shin, John Quin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pediatrics
medicine.medical_specialty Pathology biology business.industry Toxoplasma gondii Sequela Frequent opportunistic infections medicine.disease Malignancy biology.organism_classification Toxoplasmosis Pathology and Forensic Medicine Cerebral toxoplasmosis Acquired immunodeficiency syndrome (AIDS) medicine Hiv status business |
| Zdroj: | Pathology. 44:S94 |
| ISSN: | 0031-3025 |
| DOI: | 10.1016/s0031-3025(16)32871-9 |
| Popis: | Toxoplasmosis caused by Toxoplasma gondii is one the most frequent opportunistic infections among the immunocompromised patients and commonly affects the brain of those individuals with advanced human immunodeficiency virus (HIV) infection with acquired immune deficiency syndrome (AIDS). Cerebral toxoplas-mosis can be a challenging histopathological diagnosis when it presents as the early sequela of clinically unsuspected immuno-suppression. We report a case with problematic histopathological diagnosis of cerebral toxoplasmosis because of the patient’s unsuspected HIV status, the clinico-radiological impression of metastatic malignancy, and the compounded difficulty of identifying the typical T. gondii organisms in frozen section material. However, this case highlights the need to always contemplate a non-neoplastic infective cause as the basis for observed necrosis in brain biopsies, regardless of the clinical suspicion under which the histopatholo-gical examination has been requested. |
| Databáze: | OpenAIRE |
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