| Autor: |
Peat, Andrew J., Poole, Daniel S., Sheahan, Timothy P., Yevtodiyenko, Aleksey, Tran, Vy, You, Shiyun, Jeffrey, Justin J., Mehle, Andrew, Creech, Donald, Francis, Kevin P. |
| Jazyk: |
angličtina |
| Předmět: |
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| Popis: |
Reporter viruses are useful probes for studying multiple stages of the viral life cycle. Here we describe an expanded toolbox of fluorescent and bioluminescent influenza A reporter viruses. The enhanced utility of these tools enabled kinetic studies of viral attachment, infection, and co-infection. Multi-modal bioluminescence and positron emission tomography–computed tomography (PET/CT) imaging of infected animals revealed that antiviral treatment reduced viral load, dissemination, and inflammation. These new technologies and applications will dramatically accelerate in vitro and in vivo influenza virus studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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