Prognostic factors and long-term survival in oral squamous cell carcinoma

Autor:	Cacilda Castelo Branco Lima, Eduardo Salmito Soares Pinto, Ana Luisa Rios Barbosa de Almeida, Julio Cesar Saraiva Santos, Lucielma Salmito Soares Pinto, Luciana Tolstenko Nogueira, Carlos Eduardo Moura Carvalho Rocha, Rafael Everton Assunção Ribeiro da Costa
Rok vydání:	2021
Předmět:	Gynecology National health medicine.medical_specialty Cross-sectional study business.industry General Medicine medicine.disease Long term survival medicine Carcinoma Basal cell In patient business Median survival Survival analysis
Zdroj:	Scientia Medica. 31:e41124
ISSN:	1980-6108 1806-5562
DOI:	10.15448/1980-6108.2021.1.41124
Popis:	EnglishObjective: this study aimed to evaluate long-term survival and prognostic factors in patients with oral squamous cell carcinoma (OSCC) in an economically poor region of Brazil.Methods: the data were obtained from analysis of medical and mortality records of 210 patients with OSCC treated at an oncology hospital providing services to the Brazilian Unified National Health System in a State of northeastern Brazil between January 2006 and December 2008. Sociodemographic and clinical information, treatment performed, recurrence and evolution were collected. Survival curves were estimated by the Kaplan-Meier method and the log rank and Cox regression tests were used to compare the curves.Results: the median survival in the study period was 47.4 months (95% CI = 38.2 - 56.7). The overall survival rates at 5 and 10 years were 29% and 19.8%, respectivelly. Individuals over 60 years of age (HR = 1.70; 95% CI = 1.06 - 2.73), presence of regional metastasis (HR = 2.51; 95% CI = 1.55 - 4.08), presence of recurrence (HR = 3.18; 95% CI = 1.88 - 5.39) and no surgical treatment (HR = 2.10; 95% CI = 1.31 - 3.35) had a worse prognosis.Conclusions: advanced age, presence of regional metastasis, tumor recurrence and non-surgical treatment predict poorer survival in patients diagnosed with OSCC. portuguesObjetivo: este estudo objetivou avaliar a sobrevida a longo prazo e fatores prognosticos de pacientes com carcinoma espinocelular bucal em uma regiao pouco desenvolvida economicamente do Brasil.Metodos: os dados foram obtidos a partir da analise de registros medicos de 210 pacientes com carcinoma espinocelular bucal tratados em um hospital especializado em oncologia que presta servicos ao Sistema Unico de Saude em um estado do Nordeste brasileiro entre janeiro de 2006 e dezembro de 2008. Informacoes clinicas, sociodemograficas e referentes aos tratamentos realizados, recidivas e evolucoes foram coletadas. As curvas de sobrevida foram estimadas pelo metodo de Kaplan-Meier, sendo utilizado o teste de Log-rank para comparar as curvas.Resultados: a sobrevida media no estudo foi de 47.4 meses (95% IC = 38.2 - 56.7). As taxas de sobrevida global em 5 e 10 anos foram de 29% e 19.8%, respectivamente. Individuos com idade superior a 60 anos (RR = 1.70; 95% IC = 1.06 - 2.73), que apresentaram metastases regionais (RR = 2.51; 95% IC = 1.55 - 4.08), recidivas tumorais (RR = 3.18; 95% IC = 1.88 - 5.39) e que foram tratados apenas nao cirurgicamente (RR = 2.10; 95% IC = 1.31 - 3.35) tiveram pior prognostico.Conclusoes: idade avancada, presenca de metastases regionais, recidivas tumorais e tratamento apenas nao cirurgico foram preditores de pior sobrevida em pacientes diagnosticados com carcinoma espinocelular bucal.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1dc77ed3cdc51c75fe4180d1d27b6042 https://doi.org/10.15448/1980-6108.2021.1.41124 Zobrazit plný text záznamu