Roles of CaMKII in Learning and Memory ☆
| Autor: | Roger J. Colbran, Jason R. Stephenson |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal
neural and ocular physiology Nonsynaptic plasticity Long-term potentiation Biology environment and public health Cell biology nervous system Ca2+/calmodulin-dependent protein kinase Metaplasticity Synaptic plasticity cardiovascular system Excitatory postsynaptic potential Protein kinase A Neuroscience Postsynaptic density |
| DOI: | 10.1016/b978-0-12-809324-5.21106-1 |
| Popis: | There is abundant evidence showing that Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) plays critical roles in synaptic plasticity underlying learning and memory. This chapter reviews the fundamental biochemical properties of CaMKII that make it ideally suited to function as a memory molecule. However, despite the identification of numerous synaptic CaMKII substrates over the last 30 years, the molecular mechanisms that allow CaMKII to precisely modulate excitatory synaptic transmission and play key roles in synaptic plasticity remain unclear. The molecular basis for targeting CaMKII to excitatory synapses and the putative functional impact of this targeting are discussed. |
| Databáze: | OpenAIRE |
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