The Roles of Serotonin in Neuropsychiatric Disorders
| Autor: | Mehrnoosh Arabi, Reza Ahadi, Richard T. Ward, Mahsa Pourhamzeh, Mohammad Taghi Joghataei, Soraya Mehrabi, Elahe Shahriari, Fahimeh Ghasemi Moravej |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
business.industry Cell Biology General Medicine medicine.disease Serotonergic Serotonin pathway 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine Mood Mood disorders Schizophrenia medicine Autism Anxiety Serotonin medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cellular and Molecular Neurobiology. 42:1671-1692 |
| ISSN: | 1573-6830 0272-4340 |
| Popis: | The serotonergic system extends throughout the central nervous system (CNS) and the gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a broad spectrum of functions, including mood, cognition, anxiety, learning, memory, reward processing, and sleep. These processes are mediated through 5-HT binding to 5-HT receptors (5-HTRs), are classified into seven distinct groups. Deficits in the serotonergic system can result in various pathological conditions, particularly depression, schizophrenia, mood disorders, and autism. In this review, we outlined the complexity of serotonergic modulation of physiologic and pathologic processes. Moreover, we provided experimental and clinical evidence of 5-HT's involvement in neuropsychiatric disorders and discussed the molecular mechanisms that underlie these illnesses and contribute to the new therapies. |
| Databáze: | OpenAIRE |
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