Current prescription pattern of maintenance treatments for bipolar patients in Korea: A focus on the transition from acute treatments
| Autor: | Kwanghun Lee, Bo-Hyun Yoon, Jonghun Lee, Moon-Doo Kim, Won-Myong Bahk, Dae-Bo Lee, Young Joon Kwon, InKi Sohn, Young Myo Jae, Young-Chul Shin, Seunghee Won, Sang-Yeol Lee, Young Sup Woo, Hoo Rim Song, Sae-Heon Jang, Sang-Keun Chung, Hwang-Bin Lee, Jung Goo Lee |
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| Rok vydání: | 2015 |
| Předmět: |
Olanzapine
medicine.medical_specialty medicine.drug_class Lamotrigine Pharmacology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Bipolar disorder Risperidone business.industry General Neuroscience Mood stabilizer General Medicine medicine.disease 030227 psychiatry Psychiatry and Mental health Neurology Clinical Global Impression Quetiapine Aripiprazole Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychiatry and Clinical Neurosciences. 70:42-50 |
| ISSN: | 1323-1316 |
| DOI: | 10.1111/pcn.12337 |
| Popis: | Aims We examined prescription patterns in maintenance treatment for recovered bipolar patients and compared these with acute treatments. Methods Using retrospective methods, the bipolar patients in clinical recovery (Clinical Global Impression Bipolar Version score ≤ 2 for 6 months) after acute episode were selected. We reviewed differences between prescription patterns at remission and after a maintenance period of at least 6 months. Results A total of 340 bipolar disorder patients were selected. During the maintenance period, more than half of the patients (192, 56.5%) took a mood stabilizer (MS) + antipsychotic (AP) combination. Among the MS, valproate (149, 43.8%) was most prescribed, and lithium (98, 28.8%) was second, but as patients moved into maintenance treatment, lithium use decreased, and the use of lamotrigine (86, 25.3%) increased. Preferred AP were quetiapine (125, 36.8%), aripiprazole (67, 19.7%), risperidone (48, 14.1%), and olanzapine (39, 11.5%). The use of olanzapine in maintenance was greatly decreased compared with that during acute treatment (67, 19.7%). Most patients did not take an antidepressant (AD), but the proportion using one or more AD was increased during maintenance (17.9% to 30.3%), and bupropion (28, 8.2%) was the preferred AD. Doses were decreased in all drugs, but lamotrigine was maintained at a dose of 133.2 ± 68.5 mg/day. Conclusions The most common prescription combination for bipolar maintenance treatment was MS + AP. The use of AP was decreased, whereas the use of AD in combination with MS and/or AP was increased. The doses of MS and AP were generally decreased during the maintenance periods, with the exception of lamotrigine. |
| Databáze: | OpenAIRE |
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