Cancer papillaire sur goitre dyshormonogénétique
| Autor: | L. Ayadi, Mouna Mnif, B. Hammami, S. Makni, A Ghorbel, I. Bahri, Rim Kallel, L. Mnif Hachicha, Tahia Sallami Boudawara, Mohamed Abid |
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| Rok vydání: | 2009 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty Goiter endocrine system diseases business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroid Thyroidectomy Cancer General Medicine Hyperplasia medicine.disease Congenital hypothyroidism Endocrinology medicine.anatomical_structure medicine Carcinoma Differential diagnosis business |
| Zdroj: | Annales d'Endocrinologie. 70:485-488 |
| ISSN: | 0003-4266 |
| DOI: | 10.1016/j.ando.2009.08.001 |
| Popis: | Introduction Dyshormonogenetic goiter is a genetically determined thyroid hyperplasia due to an enzyme defect in thyroid-hormone synthesis. Malignant transformation is one of the most serious complications, rarely reported in the literature. Observation We report a new case of a 13-year-old boy with goitrous hypothyroidism who consulted for a voluminous goiter. Total thyroidectomy was performed. Histopathological examination revealed multiple foci of papillary carcinoma with a lymph node metastasis. Conclusion Dyshormonogenetic goiter is a rare entity, representing one of the causes of congenital hypothyroidism. It is morphologically characterized by architectural and cellular pleomorphism that may mimic thyroid malignancy and cause difficulties in differential diagnosis. |
| Databáze: | OpenAIRE |
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