Initiation of epileptiform activity in a rat model of periventricular nodular heterotopia
| Autor: | H. Jürgen Wenzel, Emily T. Doisy, Naranzogt Tschuluun, Philip A. Schwartzkroin |
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| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Methylazoxymethanol acetate Neocortex Offspring business.industry Hippocampus Bicuculline Cortical dysplasia medicine.disease Teratology Epilepsy chemistry.chemical_compound medicine.anatomical_structure Endocrinology Neurology chemistry hemic and lymphatic diseases Internal medicine medicine Neurology (clinical) business reproductive and urinary physiology medicine.drug |
| Zdroj: | Epilepsia. 52:2304-2314 |
| ISSN: | 0013-9580 |
| DOI: | 10.1111/j.1528-1167.2011.03264.x |
| Popis: | Purpose Periventricular nodular heterotopia (PNH) are, in humans, often associated with difficult-to-control epilepsy. However, there is considerable controversy about the role of the PNH in seizure generation and spread. To study this issue, we have used a rat model in which injection of methylazoxymethanol (MAM) into pregnant rat dams produces offspring with nodular heterotopia-like brain abnormalities. |
| Databáze: | OpenAIRE |
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