An Efficient Syntesis of 1,8-Naphthyridin-2(1H)-ones: Synthesis of Leukotriene Inhibitor SCH 37224

Autor:	D. Gala, Martin Steinman, P. L. Nyce
Rok vydání:	1991
Předmět:	Reaction conditions Leukotriene chemistry.chemical_compound Leukotriene release Betaine chemistry Bicyclic molecule Yield (chemistry) Organic Chemistry Alkoxide Solubility Combinatorial chemistry Catalysis
Zdroj:	Synthesis. 1991:571-574
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-1991-26519
Popis:	A new, efficient synthesis of 1,8-naphthyridin-2(1H)-ones as applied to the synthesis of the leukotriene release inhibitor, 1,2-dihydro-1-phenyl-3-pyrrolidinio-2-oxo-1,8-naphthyridin-4-olate inner salt (4) from methyl 2-phenylamino-3-pyridinecarboxylate, (1a), has been described. Towards this synthesis a new reaction procedure for the N-chloroacylation of 1 a was developed. The high yield for the rest of the synthesis was obtained by establishing reaction conditions that utilized the solubility, and the stability properties 4
Databáze:	OpenAIRE
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