Correlations of Reduced Glutathione and Glutathione Peroxidase Activities with Biochemical Markers of Liver and Kidney Damage in Trypanosoma brucei brucei Infected Rats

Autor:	B. J. Kolawole, S. Adamu, O. G. Fanaiye, K.A.N. Esievo, S. Y. Idris, J. P. Erin
Rok vydání:	2020
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Biochemistry Glutathione peroxidase Liver and kidney parasitic diseases Glutathione Biology Trypanosoma brucei biology.organism_classification Biochemical markers
Zdroj:	Sahel Journal of Veterinary Sciences. 17:1-6
ISSN:	2756-6803 1117-6210
DOI:	10.54058/saheljvs.v17i2.95
Popis:	The correlations of reduced glutathione (GSH) and glutathione peroxidase (GPx) levels with biochemical markers of liver and kidney damage in Trypanosoma brucei brucei infection were studied in rats. Forty adult male rats divided into 2 groups of control and infected were used. Infected rats were inoculated intraperitoneally with 1.0 ml of blood at concentration of 1 x 106 trypanosomes per ml. Serum and tissue samples were collected on days 0, 3, 5 and 7 post-infection (pi) for biochemical analyses. Serum GPx activity had a significant (p < 0.05) positive correlations with liver (r = 0.96) and kidney GSH (r = 0.93) levels. All the measured serum parameters had significant (p < 0.05) negative correlations with serum GPx activity. In conclusion infection of rats with T. brucei brucei caused a decrease in the serum GPx activities and organ GSH levels with increasing parasitaemia and duration of the infection.
Databáze:	OpenAIRE
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