Design and evaluation of transdermal flufenamic acid delivery system

Autor:	Georage Chiaw-Chi Hwang, Meenu Madhavan
Rok vydání:	1992
Předmět:	Pharmacology Acrylate Chromatography Stereochemistry Chemistry Organic Chemistry Pharmaceutical Science Permeation In vitro Hairless chemistry.chemical_compound Flufenamic acid Drug Discovery medicine Liberation Swelling medicine.symptom medicine.drug Transdermal
Zdroj:	Drug Development and Industrial Pharmacy. 18:617-626
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049209043714
Popis:	Monolithic-type transdermal flufenamic acid (FA) delivery systems were prepared using an acrylate pressure sensitive adhesive (PSA) which contained 3, 6 and 9% (w/w) of FA. The in vitro release profiles of these systems were examined using modified Franz diffusion cells and observed that FA is molecularly dissolved in the acrylate PSA matrix and the drug released via a solution-diffusion mechanism. Permeation studies through excised hairless mouse skin revealed that the system containing 9% of FA showed the highest flux. The 9% system was further evaluated for its anti-inflammatory effect by applying the system on carrageenan-induced paw edema in mice and concluded that significant inhibition of swelling was produced as compared to the placebo system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1d619bdf9b1b748415155d455a79e3bf https://doi.org/10.3109/03639049209043714 Zobrazit plný text záznamu