Effects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetes
| Autor: | Laurence G. Howes, D. Brillante, D. Tran, J. B. Howes |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Ambulatory blood pressure Endothelium business.industry Endocrinology Diabetes and Metabolism Type 2 diabetes Isoflavones medicine.disease Placebo chemistry.chemical_compound Endocrinology medicine.anatomical_structure Blood pressure chemistry Diabetes mellitus Internal medicine Internal Medicine medicine Vascular resistance business |
| Zdroj: | Diabetes, Obesity and Metabolism. 5:325-332 |
| ISSN: | 1462-8902 |
| DOI: | 10.1046/j.1463-1326.2003.00282.x |
| Popis: | Objective: The aim of this study was to determine whether dietary supplementation with isoflavones from red clover affected ambulatory blood pressure and forearm vascular endothelial function in postmenopausal type 2 diabetic women. Design: Sixteen postmenopausal type 2 diabetics treated with diet or oral hypoglycaemic therapy completed a randomized double-blind crossover trial of dietary supplementation with isoflavones from red clover (approximately 50 mg/day) for 4 weeks compared to placebo. Twenty-four-hour ambulatory blood pressure recordings and forearm vascular responses to acetylcholine, nitroprusside and L-nitromonomethylarginine (L-NMMA) were measured at the end of each treatment period. Results: Mean daytime systolic and diastolic blood pressures were significantly lower during isoflavone therapy compared to placebo (−8.0 ± 3.4 and −4.3 ± 1.9 mmHg respectively, p |
| Databáze: | OpenAIRE |
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