Circulating cell-free DNA in the peripheral blood plasma of patients is an informative biomarker for multiple myeloma relapse

Autor: Tadao Ishida, Arinobu Tojo, Norio Komatsu, Hideto Tamura, Junya Makiyama, Norina Tanaka, Masahiro Kizaki, Hiroshi Yasui, Yoichi Imai, Yutaka Tsukune, Junji Tanaka, Kota Sato, Kazuaki Yokoyama, Kanya Kondoh, Hiroshi Handa, Yuta Kaito, Seiya Imoto, Makoto Sasaki, Masayuki Kobayashi, Toyotaka Kawamata
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Clinical Oncology. 26:2142-2150
ISSN: 1437-7772
1341-9625
DOI: 10.1007/s10147-021-01991-z
Popis: Multiple myeloma (MM) is an incurable hematological malignancy. Despite the introduction of several novel drugs, most patients relapse. Biomarkers to identify the early signs of relapse will make it possible to adjust the therapeutic strategy before the disease worsens. Although understanding genetic changes is important for the treatment of MM, currently known biomarkers of relapse, including serum free-light chains and monoclonal paraproteins, are not associated with genetic changes. We therefore performed a multicenter study to examine the usefulness of circulating cell-free DNA (cfDNA) present in the peripheral blood (PB) plasma of patients as a biomarker for MM relapse. We identified several driver mutations by combined analysis of next-generation sequencing and existing databases of candidate oncogenes. Furthermore, relapse was detected more sensitively by monitoring the circulating cfDNA with these driver mutations than by conventional serum free-light chain examination. These results suggest the potential utility of cfDNA in the PB plasma of patients as a relevant early biomarker for MM relapse.
Databáze: OpenAIRE
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