EFFECT OF CYCLODEXTRINS ON THE STABILITY OF BILAYER: A NOVEL ELECTROPHORETIC APPROACH
| Autor: | Mohammad Ali Darbandi, Somayeh Dahmardeh, Kaveh Tabrizian, Majid Zandkarimi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
education.field_of_study Chromatography Cyclodextrin Chemistry Bilayer Clinical Biochemistry Pharmaceutical Science Model lipid bilayer Biochemistry Analytical Chemistry Membrane Capillary electrophoresis Pulmonary surfactant Dimethyldioctadecylammonium bromide Lipid bilayer phase behavior education |
| Zdroj: | Journal of Liquid Chromatography & Related Technologies. 37:2433-2443 |
| ISSN: | 1520-572X 1082-6076 |
| DOI: | 10.1080/10826076.2013.840840 |
| Popis: | In capillary electrophoresis, a common approach to prevent adsorption of an analyte onto a capillary's inner surface is to use surfactants as coating materials. These coating materials form a bilayer structure that resembles the arrangement of phospholipids (natural surfactants) in cell membranes. In this study, a bilayer coating was produced on the surface of a capillary using either a double-chained cationic surfactant, dimethyldioctadecylammonium bromide (2C18DAB), or a triple-chained cationic surfactant, tridodecylmethylammonium iodide (3C12MAI). The resulting bilayer coatings were investigated in the presence of various neutral cyclodextrins using hydrodynamic rinsing and performing successive runs. All types of cyclodextrins that were investigated had the effect of partially destabilizing the bilayer. However, cyclodextrin, as well as type of surfactant has a remarkable effect on the extent of a bilayer's stability. The most stable bilayer was obtained on capillaries coated with 2C18DAB using HP-βCD... |
| Databáze: | OpenAIRE |
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