The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer
| Autor: | Jie Li, Wentao Yue, Yan Gao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine business.industry Wnt signaling pathway Cancer medicine.disease law.invention Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology DKK1 law 030220 oncology & carcinogenesis Wnt inhibitor Cancer research Medicine Suppressor Cancer development business |
| Zdroj: | Cancer Management and Research. 12:4253-4260 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s254596 |
| Popis: | The Wnt signaling pathway extensively participates in diverse processes such as embryonic development, maintenance of homeostasis and tumor pathogenesis. Dickkopf-1 (DKK1), a Wnt inhibitor, plays a vital role for over the past decades regarding its role in the regulation of several types of cancers. However, studies have shown that DKK1 is expressed differently in cancer and plays a role as a cancer-promoting factor or a tumor suppressor, which is worthy of further exploration. We herein study whether DKK1 is highly expressed in all cancers and plays a crucial role in promoting cancer. Furthermore, we discussed as to which stages of cancer development it plays in. Finally, the present detection methods were introduced and indicated the clinical application of DKK1 in tumor development. |
| Databáze: | OpenAIRE |
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