Яд змеи Macrovipera lebetina obtusa как противоопухолевый модулятор в мышиной модели саркомы S-180
| Autor: | Sara Vaz, Luis A. Pardo, Naira Movsisyan, Joana C Macedo, Narine A. Ghazaryan, Elsa Logarinho, Naira M. Ayvazyan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
integumentary system Angiogenesis Necroptosis digestive oral and skin physiology General Medicine Pharmacology Biology biology.organism_classification complex mixtures people.cause_of_death Vascular endothelial growth factor Chorioallantoic membrane chemistry.chemical_compound chemistry Snake venom Venomous snake Macrovipera lebetina people |
| Zdroj: | Молекулярная биология. 55:468-477 |
| ISSN: | 0026-8984 |
| DOI: | 10.31857/s0026898421030071 |
| Popis: | Macrovipera lebetina obtusa (MLO) is a venomous snake endemic to Middle East. Here we describe the therapeutic potential of the MLO snake venom. In S-180 sarcoma-bearing mouse model, we showed that the MLO snake venom inhibits tumour growth by 50%. In human dermal microvascular endothelial cells (HMVEC-D), treatment with the MLO snake venom lead to an increase of expression levels of the vascular endothelial growth factor (VEGF), while the level of the expression of caspase 8 did not change. In HMVEC-D cells MLO snake venom induces necroptosis, rather than apoptosis. In the chick embryo chorioallantoic membrane (CAM) assay, exposure to MLO snake venom inhibited bFGF-induced angiogenesis by 22%. Taken together, these results indicate that the MLO snake venom has a potent cytotoxic activity. Regulated necroptic cell death pathway, which is engaged by MLO snake venom, may become a promising novel target for antitumor therapies. |
| Databáze: | OpenAIRE |
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