Investigation of clinical and laboratory manifestations of rheumatoid arthritis depending on the level of serum fetuin-A

Autor: Experimental Rheumatology named aft er A. B. Zborovsky, J. Polyakova, Yu.R. Akhverdyan, B.V. Zavodovsky, L.E. Sivordova, E.V. Papichev, Experimental Rheumatology named after A. B. Zborovsky
Rok vydání: 2021
Předmět:
Zdroj: Siberian Medical Review. :29-34
ISSN: 2500-0136
1819-9496
DOI: 10.20333/25000136-2021-2-29-34
Popis: Aim of the study. To study the association between the serum FA in patients with RA and separate clinical and laboratory manifestations of the disease. Material and methods. A total of 140 subjects were enrolled in the study. Among them, 110 were RA patients and 30 were conventionally healthy subjects. Th e level of serum FA was measured in both groups. All patients underwent complete clinical and laboratory examination and X-ray imaging of the impaired joints. Results. The level of normal FA in healthy subjects calculated as M±2σ totalled 653.55-972.19μg/ml. The mean level of FA in RA patients was 765.67±120.67μg/ ml, which is statistically lower than that in the donors: 812.95±76.21μg/ml (t=-2.03; p=0.0437). Th e mean FA level in conventionally healthy patients was statistically higher than the same index in RA-factor positive patients with cyclic citrullinated peptide antibodies, moderate and high activity, late clinical stage, X-ray stages III and IV, functional classes II, III and IV, joint erosion, abarticular manifestations and the presence of complicating diseases. Intra-group analysis (odds ratio and adjusted odd ratio) showed the patients with lower FA level (below 653.55μg/ml) to have a 14-fold higher possibility of CCP antibodies positivity (6-fold after adjustment), 1.86-fold higher disease activity (2.39-fold aft er adjustment), 6.6-fold higher probability of X-ray stage IV (with no statistical signifi cance after adjustment) and 29-fold higher chance of presence of complications (46-fold after adjustment). Conclusion. According to the data obtained in our study, lowering of the serum FA level is characteristic to RA patients. The hepatokine concentration below 653.55μg/ml may suggest 2.39-fold higher chance of higher disease activity and 46-fold higher probability of complicated RA progression.
Databáze: OpenAIRE
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