Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma
| Autor: | Anne Tuomisto, Laura Ylitalo, Päivi Sirniö, Tiina Kantola, Rami Kuivila, Markus J. Mäkinen, Karoliina Stefanius, Tuomo J. Karttunen |
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| Rok vydání: | 2011 |
| Předmět: |
Mutation rate
Histology endocrine system diseases Colorectal cancer Microsatellite instability General Medicine Methylation Biology medicine.disease medicine.disease_cause digestive system diseases Colorectal Serrated Adenocarcinoma Pathology and Forensic Medicine DNA methylation medicine Cancer research Adenocarcinoma KRAS neoplasms |
| Zdroj: | Histopathology. 58:679-692 |
| ISSN: | 0309-0167 |
| Popis: | Stefanius K, Ylitalo L, Tuomisto A, Kuivila R, Kantola T, Sirnio P, Karttunen T J & Makinen M J (2011) Histopathology58, 679–692 Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma Aims: To define the occurrence of KRAS and BRAF mutations, microsatellite instability (MSI), and MGMT and hMLH1 methylation and expression in colorectal serrated adenocarcinoma. Methods and results: KRAS codon 12/13 and 59/61 and BRAF V600E mutations, MSI, and MGMT and hMLH1 methylation and expression in 42 serrated adenocarcinomas and 17 serrated adenomas were compared with those in 59 non-serrated colorectal carcinomas (CRCs) and nine adenomas. KRAS and BRAF mutations were observed in 45% and 33% of serrated adenocarcinomas and in 27% and 0% of non-serrated CRCs (P |
| Databáze: | OpenAIRE |
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