Neutrophil-to-lymphocyte ratio and C-reactive protein–to–albumin ratio as prognostic factors for unresectable advanced or recurrent gastric cancer

Autor:	Hiroyuki Kitagawa, Shigeto Shimizu, Kazuhiro Hanazaki, Michiya Kobayashi, Masaya Munekage, Hiromichi Maeda, Keiichiro Yokota, Tsutomu Namikawa, Nobuhisa Tanioka, Sunao Uemura
Rok vydání:	2021
Předmět:	medicine.medical_specialty Performance status biology business.industry Hazard ratio C-reactive protein Histology Gastroenterology Confidence interval Cardiothoracic surgery Internal medicine biology.protein Medicine Surgery Neutrophil to lymphocyte ratio business Abdominal surgery
Zdroj:	Langenbeck's Archives of Surgery. 407:609-621
ISSN:	1435-2451 1435-2443
DOI:	10.1007/s00423-021-02356-w
Popis:	This study evaluated the prognostic value of C-reactive protein–to–albumin (CAR) and neutrophil-to-lymphocyte ratios (NLR) in conjunction with host-related factors in patients with unresectable advanced or recurrent gastric cancer. A total of 411 patients with unresectable advanced gastric cancer were treated at Kochi Medical School between 2007 and 2019. Associations between clinicopathological parameters and systemic inflammatory and nutritional markers, including CAR and NLR, with overall survival were analyzed retrospectively. The optimal cut-off values of predicted median survival time were 0.096 (sensitivity, 74.9%; specificity, 42.5%) for CAR and 3.47 (sensitivity, 64.1%; specificity, 57.5%) for NLR, based on the results of receiver operating characteristic analysis. A weak significant positive correlation was identified between CAR and NLR (r = 0.388, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1d2ed1818ef8c2c06081610d0d07cc42 https://doi.org/10.1007/s00423-021-02356-w Zobrazit plný text záznamu Full text from SpringerLink